Pronovus Bioscience, LLC

Predicting dynamic cellular protein-RNA interactions by deep learning using in vivo RNA structures

Interactions with RNA-binding proteins (RBPs) are integral to RNA perform and mobile regulation, and dynamically replicate particular mobile situations. Nevertheless, presently obtainable instruments for predicting RBP-RNA interactions make use of RNA sequence and/or predicted RNA constructions, and due to this fact don’t seize their condition-dependent nature. Right here, after profiling transcriptome-wide in vivo RNA secondary constructions in seven cell varieties, we developed PrismNet, a deep studying device that integrates experimental in vivo RNA construction knowledge and RBP binding knowledge for matched cells to precisely predict dynamic RBP binding in varied mobile situations. PrismNet outcomes for 168 RBPs assist its utility for each understanding CLIP-seq outcomes and largely extending such interplay knowledge to precisely analyze extra cell varieties.

Additional, PrismNet employs an “consideration” technique to computationally establish actual RBP-binding nucleotides, and we found enrichment amongst dynamic RBP-binding websites for structure-changing variants (riboSNitches), which may hyperlink genetic ailments with dysregulated RBP bindings. Our wealthy profiling knowledge and deep learning-based prediction device present entry to a beforehand inaccessible layer of cell-type-specific RBP-RNA interactions, with clear utility for understanding and treating human ailments.

Actual-Time Imaging of Polioviral RNA Translocation throughout a Membrane

Genome switch from a virus right into a cell is a vital early step in viral replication. Enveloped viruses obtain the supply of their genomes into the cytoplasm by merging the viral membrane with the mobile membrane through a conceptually easy mechanism referred to as membrane fusion. In distinction, genome translocation mechanisms in nonenveloped viruses, which lack viral membranes, stay poorly understood.

Though mobile assays present helpful details about cell entry and genome launch, it’s tough to acquire detailed mechanistic insights due each to the inherent technical difficulties related to direct visualization of those processes and to the prevalence of nonproductive occasions in mobile assays carried out at a really excessive multiplicity of an infection. To beat these points, we developed an in vitro single-particle fluorescence assay to characterize genome launch from a nonenveloped virus (poliovirus) in actual time utilizing a tethered receptor-decorated liposome system.

Our outcomes recommend that poliovirus genome launch is a fancy course of that consists of a number of rate-limiting steps. Apparently, we discovered that the addition of exogenous wild-type capsid protein VP4, however not mutant VP4, enhanced the effectivity of genome translocation. These outcomes, along with prior structural evaluation, recommend that VP4 interacts with RNA instantly and types a protecting, membrane-spanning channel throughout genome translocation.

Moreover, our knowledge point out that VP4 dynamically interacts with RNA, moderately than forming a static tube for RNA translocation. This examine gives new insights into poliovirus genome translocation and presents a cell-free assay that may be utilized broadly to research genome launch processes in different nonenveloped viruses.IMPORTANCE The preliminary switch of genomic materials from a virus into a bunch cell is a key step in any viral an infection. Consequently, understanding how viruses ship their genomes into cells may reveal engaging therapeutic targets.

Though typical biochemical and mobile assays have offered helpful details about cell entry, the mechanism used to ship the viral genomes throughout the mobile membrane into the cytoplasm is just not properly characterised for nonenveloped viruses corresponding to poliovirus. On this examine, we developed a fluorescence imaging assay to visualise poliovirus genome launch utilizing an artificial vesicle system. Our outcomes not solely present new mechanistic insights into poliovirus genome translocation but in addition provide a cell-free assay to bridge gaps in understanding of this course of in different nonenveloped viruses.

Towards a Complete Evaluation of Posttranscriptional Regulatory Networks: a New Device for the Identification of Small RNA Regulators of Particular mRNAs

Numerous computational or experimental instruments have been developed to establish targets of small RNA (sRNA) regulation. Right here, we modified considered one of these strategies, primarily based on in vivo proximity ligation of sRNAs sure to their targets, known as rGRIL-seq, that can be utilized to seize sRNA regulators of a gene of curiosity. Intracellular expression of bacteriophage T4 RNA ligase results in a covalent linking of sRNAs base-paired with mRNAs, and the chimeras are captured utilizing oligonucleotides complementary to the mRNA, adopted by sequencing.

This permits the identification of identified in addition to novel sRNAs. We utilized rGRIL-seq towards discovering sRNA regulators of expression of the stress response sigma issue RpoS in Escherichia coli, Pseudomonas aeruginosa, and Vibrio cholerae In E. coli, we confirmed the regulatory function of identified sRNAs and found a brand new unfavorable regulator, asYbiE. When utilized to P. aeruginosa and V. cholerae, we recognized two novel sRNAs (s03661 and s0223) in P. aeruginosa and two identified sRNAs (TfoR and Vcr043) in V. cholerae as direct regulators of rpoS The usage of rGRIL-seq for outlining a number of posttranscriptional regulatory inputs into particular person mRNAs represents a step towards a extra complete understanding of the workings of bacterial regulatory networks.

IMPORTANCE With the popularity of the significance of posttranscriptional regulation mediated by bacterial small RNAs (sRNAs), their contribution to international gene expression regulatory networks must be addressed in a very complete method. Whereas a single sRNA targets a number of RNAs, an mRNA might be regulated by a number of sRNAs that may be both transcribed individually or derived by processing of mRNAs. On this paper, we developed a device (known as rGRIL-seq) to establish sRNAs that regulate mRNAs no matter their origin.

Red RNA Lysis Kit 250
REDE5-RNA	Next Advance	250pack	EUR 746.4
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50
YELLOWE1-RNA	Next Advance	50pack	EUR 230.4
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250
YELLOWE5-RNA	Next Advance	250pack	EUR 748.8
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

RNA isolater Total RNA Extraction Reagent
R401-01	Vazyme	100 ml	EUR 159.6

Total RNA Isolation Kit
P-9100	EpiGentek	50 samples	EUR 416.7

5E Navy RNA Lysis Kit 100
NAVY5E100-RNA	Next Advance	100pack	EUR 543.6
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 20
NAVY5E20-RNA	Next Advance	20pack	EUR 183.6
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 50
NAVYR1-RNA	Next Advance	50pack	EUR 242.4
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 250
NAVYR5-RNA	Next Advance	250pack	EUR 799.2
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E GREEN RNA Lysis Kit 100
GREEN5E100-RNA	Next Advance	100pack	EUR 463.2
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20
GREEN5E20-RNA	Next Advance	20pack	EUR 165.6
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50
GREENR1-RNA	Next Advance	50pack	EUR 220.8
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250
GREENR5-RNA	Next Advance	250pack	EUR 704.4
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E PINK RNA Lysis Kit 100
PINK5E100-RNA	Next Advance	100pack	EUR 456
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E PINK RNA Lysis Kit 20
PINK5E20-RNA	Next Advance	20pack	EUR 163.2
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 50
PINKR1-RNA	Next Advance	50pack	EUR 217.2
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 250
PINKR5-RNA	Next Advance	250pack	EUR 691.2
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 100
RED5E100-RNA	Next Advance	100pack	EUR 514.8
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 20
RED5E20-RNA	Next Advance	20pack	EUR 177.6
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 50
REDR1-RNA	Next Advance	50pack	EUR 234
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 250
REDR5-RNA	Next Advance	250pack	EUR 765.6
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50
YELLOWR1-RNA	Next Advance	50pack	EUR 238.8
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 250
YELLOWR5-RNA	Next Advance	250pack	EUR 787.2
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Human Total PSA (t-PSA) ELISA Kit
PRB-5049-TOTAL-5	Cell Biolabs	5 x 96 assays	EUR 2739.6

Total RNA ExtractionMini KitAnimal Tissues
FYG301-50P	Yeastern Biotech	50 Preps	Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-100P	Yeastern Biotech	100 Preps	Ask for price

Total RNA ExtractionMini KitAnimal Tissues
FYG302-300P	Yeastern Biotech	300 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-100P	Yeastern Biotech	100 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-300P	Yeastern Biotech	300 Preps	Ask for price

Total RNA ExtractionMini KitPlant Tissues
FYG303-50P	Yeastern Biotech	50 Preps	Ask for price

Total RNA Isolation Kit II
FATRS--001	Favorgen	100 preps	EUR 369.6

Total RNA Isolation Kit II
FATRS--050	Favorgen	50 preps	EUR 259.2

Total RNA from Lupus: Colon
R1236090Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart
R1236122Hd-2	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Kidney
R1236142Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Liver
R1236149Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Lung
R1236152Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Pancreas
R1236188Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Spleen
R1236246Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Stomach
R1236248Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Uterus
R1236274Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

AnaPrep Total RNA Extraction Kit
Z1322015	Biochain	1 kit (48 extractions) Including all required plastic disposables	EUR 369.6
Description: This kit is developped for our fully automated magnetic bead-based nucleic acid extraction platform which uses preprogrammed protocols and can process up to 12 samples simultaneously. With the AnaPrep 12 Extractor you will have the option to choose and work with a wide range of sample and reagent volumes. This sturdy, realiable and user-friendly machine will save you both time and expenses while ensuring consistently high quality performance and nucleic acids for your downstream applications.

Total RNA Isolation Kit (Tissue)
P-9102	EpiGentek	50 samples	EUR 416.7

Total RNA Isolation Kit (Plant)
P-9104	EpiGentek	50 samples	EUR 416.7

xTractPure Total RNA extraction Kit
Z2212007	Biochain	1 kit	EUR 499

Rapid Animal Total RNA Extraction Kit
AT4181	Bio Basic	50Preps	EUR 105.67

Rapid Animal Total RNA Extraction Kit
AT4182	Bio Basic	250preps	EUR 242.7

Broad Range Total RNA Isolation Kit
K1341050	Biochain	1 kit	EUR 319.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA ExtractionMini KitBlood/Cultured Cell
FYG301-300P	Yeastern Biotech	300 Preps	Ask for price

Plant Total RNA Mini Kit (50prep)
FAPRK-001	Favorgen	50 preps	EUR 198

Plant Total RNA Mini Kit (100prep)
FAPRK-001-1	Favorgen	100 preps	EUR 259.2

Plant Total RNA Mini Kit (300prep)
FAPRK-001-2	Favorgen	300 preps	EUR 484.8

Plant Total RNA Maxi Kit (10prep)
FAPRK-002	Favorgen	10 preps	EUR 241.2

Plant Total RNA Maxi Kit (24prep)
FAPRK-002-1	Favorgen	24 preps	EUR 380.4

Tissue Total RNA Mini Kit (50prep)
FATRK-001	Favorgen	50 preps	EUR 198

Tissue Total RNA Mini Kit (100prep)
FATRK-001-1	Favorgen	100 preps	EUR 259.2

Tissue Total RNA Mini Kit (300prep)
FATRK-001-2	Favorgen	300 preps	EUR 484.8

Tissue Total RNA Maxi Kit (10prep)
FATRK-003	Favorgen	10 preps	EUR 241.2

Tissue Total RNA Maxi Kit (24prep)
FATRK-003-1	Favorgen	24 preps	EUR 380.4

Total RNA from Alzheimer's Disease: Brain
R1236035Alz-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Pons
R1236071Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Colon
R1236090Dia-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Colon
R1236090Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Esophagus
R1236106Dia-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Interventricular Septum
R1236130Hd-2	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Kidney
R1236142Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Liver
R1236149Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Lung
R1236152Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Diaphragm
R1236169Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Pancreas
R1236188Dia-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Pancreas
R1236188Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Rectum
R1236206Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Lupus: Small Intestine
R1236226Lup-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Spleen
R1236246Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Diabetic Disease: Stomach
R1236248Dia-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Zenoquick Whole Blood Total RNA Kit
Z5010-050	GenDepot	50 preps	EUR 578.4

Zenoquick Whole Blood Total RNA Kit
Z5010-100	GenDepot	2x50 preps	EUR 967.2

EpiQuik Total RNA Isolation Fast Kit
P-9105-050	EpiGentek	50 samples	EUR 176

96-well Total RNA Kit (1 plates)
FATRE-96001	Favorgen	1 prep	EUR 232.8

96-well Total RNA Kit (2 plates)
FATRE-96002	Favorgen	2 preps	EUR 337.2

96-well Total RNA Kit (4 plates)
FATRE-96004	Favorgen	4 preps	EUR 537.6

Total RNA Plus Mini Kit (50 prep)
FATRK-P-050	Favorgen	50 preps	EUR 214.8

Total RNA Plus Mini Kit (100 prep)
FATRK-P-100	Favorgen	100 preps	EUR 290.4

FastPure Cell/Tissue Total RNA Isolation Kit
RC101	Vazyme	50 rxn	EUR 274.8

Total RNA from Human Tumor Tissue: Adrenal
R1235004-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Bladder
R1235010-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Bone
R1235023-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Breast
R1235086-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Colon
R1235090-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Esophagus
R1235106-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Kidney
R1235142-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Liver
R1235149-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Lung
R1235152-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Nose
R1235178-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Ovary
R1235183-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Parotid
R1235190-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Rectum
R1235206-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Melanoma
R1235218A-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Stomach
R1235248-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Synoviosarcoma
R1235257-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Thymus
R1235264-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Thyroid
R1235265-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Tonsil
R1235268-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Tumor Tissue: Uterus
R1235274-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Corpus Callosum
R1236045Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Frontal Lobe
R1236051Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Occipital Lobe
R1236062Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Parietal Lobe
R1236066Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Postcentral Gyrus
R1236072Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Precentral Gyrus
R1236073Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Alzheimer's Disease: Temporal Lobe
R1236078Alz-10	Biochain	10 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Congenital heart disease: Heart
R1236122Hd-3	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart Atrium, left
R1236126Hd-2	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart Atrium, right
R1236127Hd-2	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart Ventricle, left
R1236138Hd-2	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from hypertension: Heart Ventricle, right
R1236139Hd-2	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Small Intestine
R1236226Lcs-50	Biochain	50 ug	EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Adipose
R1334003-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Bladder
R1334010-50	Biochain	50 ug	EUR 363.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Brain
R1334035-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Colon
R1334090-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Heart
R1334122-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Kidney
R1334142-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Liver
R1334149-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Lung
R1334152-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Pancreas
R1334188-50	Biochain	50 ug	EUR 409.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Placenta
R1334200-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Rectum
R1334206-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Spleen
R1334246-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Stomach
R1334248-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Mouse Normal Tissue: Testis
R1334260-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Adipose
R1434003-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Bladder
R1434010-50	Biochain	50 ug	EUR 363.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Brain
R1434035-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Colon
R1434090-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Heart
R1434122-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Kidney
R1434142-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Liver
R1434149-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Lung
R1434152-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Ovary
R1434183-50	Biochain	50 ug	EUR 355.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Pancreas
R1434188-50	Biochain	50 ug	EUR 355.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Placenta
R1434200-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Rectum
R1434206-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Spleen
R1434246-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Stomach
R1434248-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Testis
R1434260-50	Biochain	50 ug	EUR 182.4
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Thymus
R1434264-50	Biochain	50 ug	EUR 256.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Plant Normal Tissue: Arabidopsis
R1634310	Biochain	100 ug	EUR 669.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Plant Normal Tissue: Corn
R1634330	Biochain	100 ug	EUR 669.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Plant Normal Tissue: Orange
R1634340	Biochain	100 ug	EUR 669.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Plant Normal Tissue: Potato
R1634350	Biochain	100 ug	EUR 669.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Plant Normal Tissue: Rice
R1634360	Biochain	100 ug	EUR 669.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Plant Normal Tissue: Wheat
R1634390	Biochain	100 ug	EUR 669.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA - Human Adult Normal Tissue: Thymus
R1234264-10	Biochain	10 µg	EUR 643

EZ-10 Spin Column Total RNA Miniprep Kit
BS1361(SK8655)	Bio Basic	50Preps	EUR 112.98

Blood/Cultured Cell Total RNA Mini Kit (50prep)
FABRK-001	Favorgen	50 preps	EUR 198

Blood/Cultured Cell Total RNA Mini Kit (100prep)
FABRK-001-1	Favorgen	100 preps	EUR 259.2

Blood/Cultured Cell Total RNA Mini Kit (300prep)
FABRK-001-2	Favorgen	300 preps	EUR 484.8

Blood/Cultured Cell Total RNA Maxi Kit (10prep)
FABRK-003	Favorgen	10 preps	EUR 241.2

Blood/Cultured Cell Total RNA Maxi Kit (24prep)
FABRK-003-1	Favorgen	24 preps	EUR 380.4

Total RNA from Human Adult Normal Tissue: Adipose
R1234003-10	Biochain	10 ug	EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Adrenal
R1234004-50	Biochain	50 ug	EUR 213.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Appendix
R1234006-10	Biochain	10 ug	EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Bladder
R1234010-50	Biochain	50 ug	EUR 213.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Brain
R1234035-50	Biochain	50 ug	EUR 213.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Breast
R1234086-50	Biochain	50 ug	EUR 213.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

We demonstrated the utility of this strategy by figuring out constructive and unfavorable sRNA regulators of the rpoS mRNA in three bacterial species. We not solely described identified sRNAs of E. coli or P. aeruginosa that management rpoS but in addition recognized a number of new rpoS regulators in V. cholerae Due to this fact, rGRIL-seq can be utilized to establish species-specific sRNAs concentrating on a conserved mRNA, they usually seemingly play an necessary function in bacterial adaptation to particular environmental niches.